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PAWPAW Alternative Cancer Treatment

Alternative Cancer - 05/27/2009

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This web page contains extensive information about alternative cancer treatment Paw Paw. Much of this information cannot be supplied by a Paw Paw distributor or manufacturer due to FDA regulations. All information is free and kept updated. Contact information of distributors is also provided for current price information.
These Treatments are Different

You cannot pick an alternative cancer treatment the same way you pick your other medications. Despite the enthusiastic claims of well meaning people:

* Just because Paw Paw worked for someone else, that does not mean it will work for you.
* Even though there are many viable alternative cancer treatments, there isn't a "best" treatment for a certain type or stage of cancer.
* Most alternative cancer treatments only work on a minority of the people who try it.

A person's unique body chemistry seems to be the most important consideration in selecting an alternative cancer treatment. Only energy medicine offers a selection method that takes body chemisrty into account.
What to Do

Consider taking no more than two treatments, the treatment recommend by someone else or selected by your research and the treatment indicated by energy medicine testing using the Alternative Cancer Treatments Test Kit*.

Introduction

Paw Paw extract contains (among other active ingredients) acetogenins which modulate the production of ATP** in mitochondria of cancer cells. This reduces the growth of blood vessels that nourish cancer cells. It also inhibits the growth of MDR (multiple drug resistance) cells. No other alternative or conventional cancer treatment (except treatments from trees similar to Paw Paw) has shown any effectiveness against MDR cells.

Paw Paw is a cousin of the graviola, guanabana, and soursop trees. However, the acetogenins extracted from Paw Paw are more active against cancer than those extracted from these other sources.

Multiple Drug Resistant Cells
Most tumors contain a small percentage, approximately 2%, of multiple drug-resistant cells (MDR cells). Chemo is not effective against these cells. After the first round of chemo, if the chemo is effective, all of the cells that are not MDR, are destroyed. Since this accounts for the vast majority of the tumor mass, the tumor will appear to be effectively destroyed. However, the MDR cells remain and start to multiply. Eventually, a new tumor is formed that is entirely MDR. The next time chemo is used, none of the cells will be destroyed because they are all MDR. Paw Paw and Graviola are the only cancer treatment that have shown effectiveness against MDR cells.

Development

Paw Paw research was performed at Purdue College by Jerry McLaughlin. The majority of the funding (20 years and about 5 million dollars) for this research was provided by NCI. Jerry McLaughlin now works with Nature Sunshine who manufacture Paw Paw twig extract in capsule form.

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Pharmacology

One of the effects of Paw Paw is to reduce the ATP energy in each cell of our body. Our cells have an electrical potential that effects how the cell processes energy producing substances mostly blood sugar and oxygen from our blood supply

By reducing this voltage level from 70 to 110 mv to something in the 50 mv region, normal cells can still function. However, cancer and viral cells cannot process energy at this low voltage level and start to starve. The process of starving is a slower process than being poisoned which is why Paw Paw works slower than chemo. When Paw Paw does not work, it is usually because it is not absorbed sufficiently into the cells of the body to cause this voltage reduction. Both Cantron and Protocel are designed to cause this voltage reduction. If Paw Paw does not work for a person, Cantron or Protocel may work. The pharmacology of Cantron and Protocel have an expanded explanation for the role ATP energy reduction in cancer treatment, for this text see the developer's explanation summarized by the webmaster Paul Winter .

Click this link for a 37 page, scientific paper (not for the laymen) on Paw Paw twig extract written in 1999 entitled "Annonaceous Acetogenins: Recent Progress."

Blood Brain Barrier

Paw Paw is one of the few alternative cancer treatments that can pass the blood/brain barrier. The other alternative cancer treatments that can cross this barrier are Cantron and Protocel.
Effectiveness

Paw Paw seems to work on all types of cancers. An informal study of 100 cancer patients showed that Paw Paw was effective in half the cases. This is most interesting since Paw Paw seems to work the same way that Cancell works and Cancell also has a 50% effectiveness as demonstrated in another informal study. However, Paw Paw gets higher marks in the effectiveness because, in the laboratory, it inhibits the growth MDR (multiple drug resistance) cells. No other cancer treatment including chemo has shown any effectiveness against MDR cells. Jerry McLaughlin is in the negotiation process for starting clinical trials in conjunction with Harvard University. However, no formal clinical trials have yet occurred. For more on MDR cells, see the "Multiple Drug Resistant Cells" section above.
Studies

Here are a few abstracts from studies conducted at Purdue University where most of the Paw Paw research for the past 30 years was conducted:

ABSTRACT: Cancer Letters 115 (1997) 73-79 The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. Nicholas H. Oberlies, Vicki L. Croy, Marietta L. Harrison, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.

Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.

ABSTRACT: Journal of Medicinal Chemistry 1997, 40, 2102-2106 Structure-activity relationships of diverse Annonaceous acetogenins against multidrug-resistant human mammary adenocarcinoma (MCF-7/Adr) cells Nicholas H. Oberlies, Ching-jer Chang, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.

Fourteen structurally diverse Annonaceous acetogenins, representing the three main classes of bis-adjacent, bis-nonadjacent, and single-THF ring(s), were tested for their ability to inhibit the growth of adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) cells. This cell line is resistant to treatment with adriamycin, vincristine, and vinblastine and is, thus, multidrug-resistant (MDR). Among a series of bis-adjacent THF ring acetogenins, those with the stereochemistry of threo-trans-threo-trans-erythro (from C-15 to C-24) were the most potent with as much as 250 times the potency of adriamycin. A spacing of 13 carbons between the flanking hydroxyl of the THF ring system and the gamma-unsaturated lactone seems to be optimum with a spacing of 11 and 9 carbons being significantly less active. Several single-THF ring compounds were also quite potent, with gigantetrocin A (11) being the most potent compound tested. The acetogenins may, thus, have chemotherapeutic potential, especially with regard to MDR tumors.

Copies of the journal articles mentioned in the story are available from the Purdue News Service, (765) 494-2081.

Additional Paw Paw research papers can be see at PawPawResearch.com
Quantity of Papers

There have been over 100 scientific papers published on the chemistry and biology of the paw paw compounds.

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Paw Paw and Viruses

ATP is a direct and indirect precursor of DNA and RNA. This can slow or stop viral reproduction for viruses such as cold sores and shingles. Although the test results below show encouraging antiviral effect, it seems that Cancell (Cantron and Protocel) has a stronger antiviral effect. On the other hand Paw Paw has shown anecdotal evidence of being a strong anti-bacterial agent.

Conclusiveness of Papers

Almost all but research papers regarding Paw Paw demonstrate significant effectiveness in the laboratory against the usual form of cancer cells and MDR cells.

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Standalone Ability

Considering the performance of Paw Paw against MDR cells, it would appear that Paw Paw would stand alone as a cancer treatment very well. However, the manufacture and developer feel that the following supplements would aid Paw Paw:

*
Immune Stimulator
*
Protease Plus

These supplements can be purchased from the same distributors that sells Paw Paw. Distributors.
Cantron or Protocel and Paw Paw
You can take Protocel with Paw Paw, but don't forget to read all the Paw Paw protocols besides these. Some people respond very quickly to Cantron or Protocel. In this case the body may have excessive waste material to remove. Paw Paw can increase the response of your body and overload the waste removal system. To present this overload, some people start Paw Paw 3 to 5 weeks after starting Cantron or Protocel. Recommended dose for Paw Paw is 1 capsule four times a day at the same time as Protocel or Cantron. Since the recommended dose for Cantron or Protocel is six times a day, you would skip taking Paw Paw for two of the Cantron or Protocel doses.

Since Paw Paw is fat soluble it will work better after a person has started eating for the day. Therefore, some users start taking Paw Paw with the second dose of Cantron.

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Ease of Use and Dosage

Paw Paw is easy to use. You only need four capsules, evenly spaced out during the day, and taken with some food.

People who change their eating habits greatly increase the effectiveness of the supplements they take. Consider reading the "General Diet*" subsection of the Home page.
Dosage

The manufacturer's recommendation is to take 1 capsule with food four times a day at even intervals with food to avoid nausea.
Increased Dosage

Some people have had success gradually increasing the Paw Paw dosage up to 16 capsules a day. They have done this very gradually in order to avoid nausea.
Paw Paw and Cantron or Protocel

It is suggested to avoid food for 15 minutes before and after taking Cantron or Protocel, but to take Paw Paw with food. Taking Cantron or Protocel fifteen minutes before or after taking Paw Paw with some food dose not seem to have a significant effect on the the performance of either treatment.

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Side Effects

Paw Paw gravitates toward cells that use a lot of energy and cut off their energy supply. Since cancer cells use 10-17 times as much energy as a normal cell, Paw Paw acts on cancer cells. It is the same mechanism that made it so useful as a parasite cleanse and to kill hair lice. It is also the reason that a pregnant woman should not take it. Paw Paw could see the baby as a high energy user.

If no cancer, parasite, or other high energy consumer cells reside in the body, Paw Paw may gravitate towards fast growing cells lining the digestive and intestinal system walls. This results in a stomach ache. This is why the manufacturer, Nature's Sunshine, strongly cautions against long term use for non-cancer patients.

Some people with cancer have reported digestion distress such as nausea. For this reason it is recommended to take Paw Paw with food.

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Compatibility
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Paw Paw seems to work in a similar manner to Cancell and may reduce the side effects of chemo, but does not interfere with chemo.

One of the ways that Paw Paw works is to prevents cancer cells from feeding on glucose by reducing the ATP energy of the cells in our body. The substances in the following list increase ATP energy and should therefore be avoided when taking Paw Paw.
Avoid

*
Vitamin C*
*
Vitamin E*
*
Co-Q10
*
Thyroid Support products
*
7-Keto-¢
* Sulfhydrazly antioxidants which includes:
L-cysteine
N-acetylsteine
Glutathione
* Burdock Root
* Essiac and Flor-Essence (which is similar to Essiac with a couple of extra ingredients)
* Ozone treatments ( oxygen treatments such as hyperbaric oxygen are acceptable)
* Flax seed oil as used with the Budwig Diet (it is starting to appear that flax seed oil may be compatible, but it remains on this list as a precaution)
* Hydrogen peroxide
* Grapefruit seed extract (due to its high vitamin C content)
* Whey protein should also be avoided because of the L-cysteine

* The amount of these vitamins found in fruits and vegetables will not have a serious effect on the performance of Paw Paw.
Year Available

Paw Paw was made available for purchase by Nature's Sunshine in 2003. Since Paw Paw and graviola are so closely related it should be noted that graviola has been under study and some use since the 1940's.
Relative Cost per Month

A one-month supply of Paw Paw costs $35. This makes Paw Paw one of the least expensive alternative cancer treatment available. Each capsule contains 12.5 mg of standardized paw paw extract.

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Testimonials and Belief

Testimonials can be a very powerful tool to help in the healing process because they can boost your belief in a treatment. However, reading testimonies is a poor method of making a treatment selection. An alternative cancer treatment with only a 5% success rate can still obtain many genuine and impressive testimonials. A selected group of positive testimonials cannot compare to a published study were all of the qualified case histories are presented, the failures as well as the successes.

For the above reason, it is not a good idea to use testimonials to help you select a cancer treatment. Save testimonials for the role that they perform the best, bolstering belief after treatments have been selected. Using an Alternative Cancer Treatment Test kit is a much better method of selecting a treatment.

Manufacturers

Since you are about to leave this web site, make sure that you have read the important Conflict Connection text which is located in a few places on this site:
Conflict Connection
When using alternative cancer treatments, the greatest threat to your success will be treatment conflicts. Some vitamins, minerals, and even herbs are known to conflict with different alternative cancer treatments. From 1997 to 2001 this web site collected hundreds of case histories. They showed that more than 30% of the responders took substances that conflicted with each other.

to a read a popup about a recently uncovered conflict. It is a perfect example of the difficulty of predicting conflicts. You can use energy medicine to test for conflicts the same way you can test treatments against your body chemistry, use the Alternative Cancer Treatments Test Kit*.

Before you order, make sure that you understand the pros and cons of the treatment selection method you used. If that method didn't take your unique body into account, consider going back and reading Understanding Treatment Selection*. You will learn why the best treatment on paper is correct for groups, but possibly wrong for an individual. With the right tools, an individual can take advantage of a better method of treatment selection.

There is only one manufacturer of standardized Paw Paw (guaranteed dose) , Nature's Sunshine. Nature's Sunshine's Paw Paw product development was overseen by Jerry McLaughlin who researched Paw Paw for twenty years at Purdue College.
International Distributors

Go to the Nature's Sunshine Products** page and click on Select a Country in the upper right corner. If your country isn't listed, go to John & Roxanne Howlett's international ordering page** (see their other contact information just below).
United States Distributors

These two distributors offer member discounts to everyone and are very knowledgeable:

John & Roxanne Howlett Nature's Sunshine Regional Managers For ordering online in the US** or for ordering overseas**. Although John & Roxanne are prevented, by FDA regulations, from making medical claims, they make themselves available to discuss protocols by email questions@healthy-sunshine.com or at their toll free ordering number: 888 523-1727.

New Beginnings in Health For ordering online in the US**. You can call Richard or Angela on their toll free ordering number to talk about taking Paw Paw, but they want people to understand that they do not have medical training and are not allowed to guarantee effectiveness: 877 871-6262. You can also visit their educational web site, PawPaw.Tv** or email your questions to lundpix@mac.com Ask for the free DVD of Dr. McLaughlin's lecture about Paw Paw.